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Previous studies from our group demonstrated that GLP-1RAs provide protection against steatohepatitis in high-fat diet (HFD)-induced obese mice [17], and against high phosphate-induced vascular calcificationa hallmark of atherosclerosisthrough AMPK activation [18]

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As scientific understanding of metabolic regulation continues to evolve, retatrutide stands as an example of how advances in peptide engineering can expand the possibilities for innovative therapeutic research.

However, restoring hormonal balance may improve overall metabolic capacity and energy levels, potentially supporting better adherence to dietary and activity goals alongside semaglutide therapy